fentanyl transdermal and diazepam both of those improve sedation. Steer clear of or Use Alternate Drug. Restrict use to patients for whom different therapy choices are insufficient
oxcarbazepine will decrease the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Continuously keep an eye on very important indicators throughout sedation and recovery time period if coadministered. Thoroughly titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
Keep track of Carefully (one)enasidenib will enhance the stage or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism.
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If any withdrawal response develops, take into account pausing taper or escalating dose to prior tapered dosage stage; subsequently lower dose more bit by bit
diazepam will enhance the amount or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A substrate) with weak CYP3A inhibitors is unavoidable, cut down to, or continue on lonafarnib at setting up dose.
fosaprepitant will increase the stage or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Oral: Details not available No dose adjustment proposed Except if administered for prolonged period; reduce dose in extended intervals
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Prevent or substitute another drug for these medications when feasible. Appraise for loss of therapeutic result if medication must be coadministered.
artemether/lumefantrine will decrease the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Observe Intently (one)belzutifan will lessen the extent or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Lively metabolites: N-desmethyldiazepam and more info temazepam, which can be both further metabolized to oxazepam; mainly removed by glucuronidation